
There are two reasons that we recommend completing the three main planets before going to Virmire - the first is that the story flows better if Virmire comes last. Honestly, we’d also recommend completing the entirely optional Asteroid X57 mission, too. We recommend that regardless of which two you complete first, you should complete all three main story planets before heading to Virmire - so despite the council's urgings and fears about the Salarian team being in danger, go ahead and do that third planet first.Īs an aside, if by the point Virmire unlocks you haven’t played Therum, you should absolutely do this first, as it allows you to get Liara, another squad member.

Virmire will unlock after you complete two of the three core story missions of Mass Effect - that’s Therum, Noveria, and Feros. Shepard and team get word of a Salarian team that has a lead on Saren - and so you’ll be sent in to investigate. While Virmire isn’t quite the point of no return for Mass Effect as a whole, it is probably the single most significant story mission in the game. Mass Effect Virmire Mission: what to know before starting
